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Instructions for Use (IFU)
Product Allergens
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Return Policy
Items returned within 30 days of purchase with a return authorization number on the outside and inside of the return box will be credited 100%. Product returned between 31 and 60 days from purchase date is subject to a 20% restocking fee. Ultradent will not accept returns after 60 days. Errors in shipment must be reported within 14 days of invoice date. All return authorization numbers become invalid 90 days after date of issue. A return authorization number must accompany all returns to receive proper credit. Please contact Customer Service at 800.552.5512 for assistance.
Limited Warranty
When your patients are ready for their brightest smile, there's not time to waste. Opalescence Pro whitening safely provides excellent whitening results in about an hour.1
The powerful 40% hydrogen peroxide gel is chemically activated, meaning no LED teeth whitening lights are necessary with Opalescence teeth whitening, as lights do not affect the whitening results.2 Opalescence Pro whitening's syringe-to-syringe mixing configuration ensures each application has fresh gel and maximum strength. Its distinct red color helps you properly place the gel and ensures complete removal, while the thicker formula prevents the gel from running.
- Whitens up to 5 shades in about an hour1
- Two to three 20-minute applications
- Powerful 40% hydrogen peroxide gel
- Contains potassium nitrate and fluoride for patient comfort
- Chemically activated, so no light is needed
- No refrigeration required prior to mixing
- Use with Black Mini™ Tip and Umbrella™ tongue, lip, and cheek retractor
- Vegan—no animal products
- Certified gluten free

New Look, Same Incredible Results
Opalescence Boost whitening is
now Opalescence Pro whitening.
The red, 40% hydrogen peroxide, in-office whitening gel you know and love isn’t changing, so you can expect the same results with a new name and look on the packaging.


High-Impact, Professional Teeth Whitening
Backed by over 35 years of experience and 100 million smiles whitened,3 Opalescence whitening ensures high-quality, professional results every time. Opalescence Pro in-office whitening delivers bright results in just one visit. With just two or three 20-minute treatments, its powerful 40% hydrogen peroxide formula provides noticeable results in as little as one hour.1 In most cases, teeth will continue to whiten 24–48 hours after the treatment, so your patients will keep smiling long after they leave your dental chair.
Teeth Whitening Results You and Your Patients Can Trust
For patients with tough stains or upcoming events, you can trust Opalescence Pro whitening to deliver brighter smiles. Opalescence Pro whitening offers brighter, whiter teeth after about an hour in the dental chair.1 See the results for yourself.*
*All results presented are specific to each patient. Individual results may vary.
See below for additional treatment details.
Chemically Activated In-Office Whitening, No Light Needed
Some in-office whitening procedures rely on lights or lasers to activate the chemical whitening agent. However, Opalescence Pro in-office whitening relies solely on chemical activation. Studies have confirmed that the whitening agent is effective without any lasers.4, 5
Opalescence Pro teeth whitening gel’s innovative double-syringe mixing configuration ensures fresh teeth whitening gel for each application. Because the gel is chemically activated, no refrigeration is required prior to mixing.

Professional Teeth Whitening in About an Hour1
Opalescence Pro in-office teeth whitening gel is the best way to whiten teeth quickly. Start by taking an initial shade of your patient’s teeth and protect your patient’s lips and gums with an Umbrella™ tongue, lip, and cheek retractor and OpalDam™ Green resin barrier. Then, apply Opalescence Pro whitening gel with a Black Mini™ tip and let it sit for 20 minutes. Depending on the results, you can reapply the gel one or two more times, for a total of two to three applications.
2–3 in-office applications
20 minutes per application

Ready for brighter smiles?
Your patients deserve the smile of their dreams, and you deserve an in-office whitening product with reliable results that doesn’t require additional investment in lights or lasers. Don’t wait! Order Opalescence Pro teeth whitening and look forward to brighter smiles and better days.
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Technical Details
Formulated with High Water Content
Many whitening products on the market dehydrate teeth, resulting in uncomfortable sensitivity for patients. Opalescence Pro teeth whitening gel is made up of at least 20% water content to help keep your teeth hydrated. Opalescence gel is effective in helping reduce shade relapse as compared to competitor tooth whitening products.3, 4
Contains Potassium Nitrate and Fluoride
No Refrigeration Required Prior To Mixing
Vegan and Certified Gluten Free
Opalescence Pro whitening gel is vegan, meaning no animal products are used. It is also certified gluten free by the Gluten Intolerance Group of North America (GFCO), an independent, third-party certification program for gluten-free products. This means it fits in with the lifestyles and beliefs of patients from diverse backgrounds.
Made in the USA from Globally Sourced Materials
Clinicals
Results from Opalescence Pro Whitening and Combination Treatments

Before. (Photo courtesy of Carol Jent, RDH.)

Results after three twenty-minute applications of Opalescence Pro whitening followed by two weeks of Opalescence™ Custom 10% teeth whitening. (Photo courtesy of Carol Jent, RDH.)

Before. (Photo courtesy of Dr. Andrea Brito.)

Results after two twenty-minute applications of Opalescence Pro whitening followed by one box of Opalescence Go™ prefilled whitening trays. (Photo courtesy of Dr. Andrea Brito.)

Before. (Photo courtesy of Carol Jent, RDH.)

Results after seven twenty-minute applications of Opalescence Pro whitening and seven months of Opalescence Custom whitening. (Photo courtesy of Carol Jent, RDH.)

Before. (Photo courtesy of Dr. Jaleena Fischer-Jessop.)

Results after two fifteen-minute applications of Opalescence Pro whitening. (Photo courtesy of Dr. Jaleena Fischer-Jessop.)

Before. (Photo courtesy of Dr. Anna Massiel Navráez.)

Results after two twenty-minute applications of Opalescence Pro whitening and one box of Opalescence Go prefilled whitening trays. (Photo courtesy of Dr. Anna Massiel Navráez.)

Before. (Photo courtesy of Carol Jent, RDH.)

Results after one twenty-minute application of Opalescence Pro whitening followed by one box of Opalescence Go prefilled whitening trays. (Photo courtesy of Carol Jent, RDH.)
Procedures
Opalescence Pro Whitening Procedure
See Instructions for Use for complete instructions, warnings, and precautions.
Step 1

Ensure syringes are securely attached. Depress the small clear plunger (A) into the middle small clear syringe (B) to rupture internal membrane and combine whitener and activator. Press the plunger of the red syringe, pushing all contents into the clear syringe.
Step 2

Press the contents of the clear plunger completely back into the red syringe. To thoroughly mix activator with whitening gel, push stems back and forth continually and mix 25 times each side.
Step 3

Press all mixed gel into the red syringe. Twist to separate the two syringes and securely attach the Black Mini™ tip onto the red syringe.
Step 4

Verify flow, consistency, and red color before applying intraorally. If resistance is met, replace tip and re-check. If gel is not red, do not use and refer to Step 2 in the Use – Mixing Opalescence Pro In-Office Whitening section of IFU.
Step 5

Remove Luer lock cap from OpalDam™ resin barrier and securely attach recommended delivery tip. Verify flow prior to applying intraorally. Rinse and dry teeth and gums thoroughly. Place Ultradent IsoBlock™ bite block and Umbrella™ retractor.
Step 6

Apply OpalDam resin barrier along gingival margin, overlapping approximately 2–3 mm onto enamel. Begin and finish one tooth beyond the most distal tooth being whitened. Express through any open embrasures to completely cover exposed papilla.
Step 7

Use mouth mirror to ensure there is no exposed gingiva. If so, apply resin. Light cure using a scanning motion. Carefully check cure.
Step 8

Apply a 0.5–1.0 mm layer of gel. Allow gel to remain on the teeth 20 minutes per application, and periodically check on patient comfort and suction saliva.
Step 9

Suction gel from teeth using the Luer Vac and SST™ (Surgical Suction Tip). Do not use water to avoid gel splatter.
Step 10

When no gel is visible, lightly rinse and air dry. Do not to dislodge isolation barrier or rubber dam seal. Monitor patient for sensitivity and irritation. If persistent sensitivity occurs, discontinue use.
Step 11

Evaluate shade change after each application. Repeat steps 8–10 for no more than 3 applications. Do not exceed 3 applications per visit. Re-treat as necessary using professional judgement.
Step 12

Gently slide the tip beneath the resin barrier to remove.
Frequently Asked Questions
-
How does teeth whitening work?
Opalescence whitening gels contain a powerful whitening ingredient, either carbamide peroxide or hydrogen peroxide. Peroxide gels break down into water, oxygen, and reactive oxygen molecules. These reactive oxygen molecules oxidize the bonds of discolored stain molecules. By changing the stained molecules, the tooth appearance becomes lighter.5
Reactive oxygen molecules permeate the entire tooth, so there is no need for the whitening agent to be in contact with every surface of the tooth for the entire tooth to be whitened.5
-
Will teeth whitening affect bond strength?
We recommend abstaining from any whitening treatments for 7–10 days before a bonding procedure.6, 7, 8 -
How long do teeth whitening results last?
Tooth whitening results can last a year or more.10, 9 Teeth whitening results are very stable, but depending on the patient’s nutrition and lifestyle habits, the procedure may need to be redone periodically. -
Will teeth whitening cause sensitivity?
Tooth sensitivity can occur as a result of whitening. If sensitivity occurs, it is transient and disappears after the completion of whitening treatments. If desensitizing treatments are desired, we recommend the use of UltraEZ™ desensitizing gel or Enamelast™ fluoride varnish. Opalescence™ Whitening Toothpaste Sensitivity Relief can also be used to help to prevent or lessen sensitivity if it occurs.